Active Human Caspases Group I, Active Human recombinant protein
Active Human Caspases Group I, Active Human
|Calculated MW||49736 Da|
|Gene ID||CASP1- 834 CASP4- 837 CASP5 -838|
|Gene Symbol||CASP1 CASP4 CASP5|
|Application Notes||Reconstitute to 1 unit/ µl in PBS containing 15% glycerol.|
|Storage||-70°C; Lyophilized powder|
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Provided below are standard protocols that you may find useful for product applications.
The caspase family consists of more than 10 members. Based on their extended substrate specificities, these enzymes were divided into three major groups: Group I (contains caspase-1,-4,-5), Group II (contains caspase-2,-3,-7), and Group III (contains caspase-6,-8,-9,-10). Evidences have suggested that Group I caspases are involved primarily in the production of inflammatory cytokines, while group II and III enzymes function in apoptosis as effectors and upstream activators, respectively. The group I caspases were expressed in E. coli and routinely tested for their ability to enzymatically cleave the substrate YVAD-pNA (for caspase-1) and WEHD-pNA (for caspase-4 & -5).
Eckhart L.,et al.Biochem. Biophys. Res. Commun. 348:682-688(2006).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Taylor T.D.,et al.Nature 440:497-500(2006).
Munday N.A.,et al.J. Biol. Chem. 270:15870-15876(1995).
Faucheu C.,et al.Eur. J. Biochem. 236:207-213(1996).
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