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Active Human Caspases Group I, Active Human recombinant protein

Active Human Caspases Group I, Active Human

Product info
Primary Accession P51878
Calculated MW 49736 Da
Additional Info
Gene ID CASP1- 834 CASP4- 837 CASP5 -838
Gene Symbol CASP1 CASP4 CASP5
Gene Source Human
Source E. coli
Assay&Purity SDS-PAGE;
Assay2&Purity2 HPLC;
Recombinant Yes
Application Notes Reconstitute to 1 unit/ µl in PBS containing 15% glycerol.
Format Lyophilized
Storage -70°C; Lyophilized powder
Citations (0)

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The caspase family consists of more than 10 members. Based on their extended substrate specificities, these enzymes were divided into three major groups: Group I (contains caspase-1,-4,-5), Group II (contains caspase-2,-3,-7), and Group III (contains caspase-6,-8,-9,-10). Evidences have suggested that Group I caspases are involved primarily in the production of inflammatory cytokines, while group II and III enzymes function in apoptosis as effectors and upstream activators, respectively. The group I caspases were expressed in E. coli and routinely tested for their ability to enzymatically cleave the substrate YVAD-pNA (for caspase-1) and WEHD-pNA (for caspase-4 & -5).


Eckhart L.,et al.Biochem. Biophys. Res. Commun. 348:682-688(2006).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Taylor T.D.,et al.Nature 440:497-500(2006).
Munday N.A.,et al.J. Biol. Chem. 270:15870-15876(1995).
Faucheu C.,et al.Eur. J. Biochem. 236:207-213(1996).

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$ 295.00
Cat# PBV11432r
(40 western blots)
Availability: 5-7days
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