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Caspases Group III, Active Human recombinant protein

Caspases Group III, Active Human

Product info
Primary Accession Q92851
Calculated MW 58951 Da
Additional Info
Gene ID CASP6- 839 CASP8- 841 CASP9- 842 CASP10- 843
Gene Symbol CASP6 CASP8 CASP9 CASP10
Gene Source Human
Source E. coli
Assay&Purity SDS-PAGE;
Assay2&Purity2 HPLC;
Recombinant Yes
Application Notes Reconstitute to 1 unit per µl in PBS containing 15% glycerol
Format Lyophilized
Storage -70°C; Lyophilized powder
Citations (0)

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Caspase family consists of more than 10 members. Based on their extended substrate specificities, these enzymes were divided into three major groups: Group I (contains caspase-1,-4,-5), Group II (contains caspase-2,-3,-7), and Group III (contains caspase-6,-8,-9,-10). Evidences have suggested that Group I caspases are involved primarily in the production of inflammatory cytokines, while group II and III enzymes function in apoptosis as effectors and upstream activators, respectively. The Group III recombinant caspases were expressed in E. coli and routinely tested for their ability to enzymatically cleave the substrate VEID-pNA (for caspase-6), IETD-pNA (for caspase-8 & -10) and LEHD-pNA (for caspase-9), respectively.


Fernandes-Alnemri T.,et al.Proc. Natl. Acad. Sci. U.S.A. 93:7464-7469(1996).
Vincenz C.,et al.J. Biol. Chem. 272:6578-6583(1997).
Ng P.W.,et al.J. Biol. Chem. 274:10301-10308(1999).
Hadano S.,et al.Genomics 71:200-213(2001).
Vonarbourg C.,et al.Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.

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$ 425.00
Cat# PBV11434r
(40 western blots)
Availability: 5-7days
Bulk Size
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