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APP (His-tagged), human recombinant

ABPP, APPI, APP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, CVAP, PreA4,

     
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Product info
Primary Accession P05067
Concentration 1 mg/ml 
Calculated MW 34.7 kDa
Additional Info
Gene ID 351
Other Names ABPP, APPI, APP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, CVAP, PreA4, Protease nexin-II, PN-II, Amyloid beta A4 protein
Gene Source Human
Source E. coli
Assay&Purity SDS-PAGE;>85%
Recombinant Yes
Sequence Leu18 - Glu289
Target/Specificity APP
Format Liquid
Storage -20°C;Liquid
Citations (0)

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Background

APP, also known as amyloid beta A4 protein, functions as a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).

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$ 155.00
$ 575.00
Cat# PBV11453r-10
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