Human CellExp™ TIM3/HAVR2 Protein, Human Recombinant
Hepatitis A virus cellular receptor 2, HAVcr-2, T-cell immunoglobulin and mucin domain-containing pr
|Calculated MW||This protein is fused with polyhistidine tag at the C-terminus, has a calculated MW of 20.7 kDa. The predicted N-terminus is Ser 22. DTT-reduced Protein migrates as 28-48 kDa due to glycosylation.|
|Other Names||Hepatitis A virus cellular receptor 2, HAVcr-2, T-cell immunoglobulin and mucin domain-containing protein 3, TIMD-3, T-cell immunoglobulin mucin receptor 3, TIM-3, T-cell membrane protein 3|
|Source||HEK 293 cells|
|Sequence||Ser 22 - Arg 220|
|Application Notes||Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH7.4) to a stock solution of 400 µg/ml. Solubilize for 30 to 60 minutes at room temperature with occasional gentle mixing. Carrier protein (0.1% (W/V) HSA or BSA) is recommended for further dilution and long term storage.|
|Storage||4°C in lyophilized state;Lyophilized powder|
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Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9.
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