Register or Login
All
  • All
  • Uniprot Id
  • Catalog #
  • Peptide Sequence
COVID19
>   home   >   Products   >   Proteins   >   Cyclin-dependent kinase inhibitor 2A_TAT, Human Recombinant   

Cyclin-dependent kinase inhibitor 2A_TAT, Human Recombinant

p16-INK4a, Cyclin-Dependent Kinase Inhibitor 2A, Cyclin-Dependent Kinase 4 Inhibitor A, CDK4I, p16IN

     
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product info
Primary Accession P42771
Calculated MW 18 kDa
Additional Info
Gene ID 1029
Other Names p16-INK4a, Cyclin-Dependent Kinase Inhibitor 2A, Cyclin-Dependent Kinase 4 Inhibitor A, CDK4I, p16INK4A, p16-INK4, Multiple Tumor Suppressor 1, MTS-1
Gene Source Human
Source E. coli
Assay&Purity SDS-PAGE;≥95%
Assay2&Purity2 HPLC;≥95%
Recombinant Yes
Sequence Full-length human Cyclin-dependent kinase inhibitor 2A and a 12-residue C-terminal TAT peptide (GYGRKKRRQRRR)
Target/Specificity Cyclin-dependent kinase inhibitor 2A-TAT
Application Notes Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml. Do not vortex. Additional carrier protein (example 0.1% BSA) is recommended for long term storage.
Format Dry powder
Storage -80°C;Lyophilized powder
Citations (0)
citation

Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.

Submit your citation using an Abcepta antibody to
info@abcepta.com, and receive a free "I Love Antibodies" mug.

Background

Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein. This activity has the effect of suppressing tumor formation and growth, and of inducing replicative senescence in various normal cells, including stem cells. The expression of Cyclin-Dependent Kinase Inhibitor 2A steadily increases with age, and tends to accumulate in stem cell compartments. The deletion, rearrangement, or mutation of the Cyclin-Dependent Kinase Inhibitor 2A gene is frequently found in melanomas, as well as in certain other types of cancer. TAT is a cell penetrating peptides (CPPs) and was shown to enable the introduction of nucleic acids into cells.

FeedBack
Abcepta welcomes feedback from its customers.

If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.

If you have any additional inquiries please email technical services at tech@abcepta.com.

Discontinued
Cat# PBV11463r-20
Size:
Alternative Products:

Ordering Information

United States
AlbaniaAustraliaAustriaBelgiumBosnia & HerzegovinaBrazilBulgariaCanadaCentral AmericaChinaCroatiaCyprusCzech RepublicDenmarkEstoniaFinlandFranceGermanyGreeceHong KongHungaryIcelandIndiaIndonesiaIrelandIsraelItalyJapanLatviaLithuaniaLuxembourgMacedoniaMalaysiaMaltaNetherlandsNew ZealandNorwayPakistanPolandPortugalRomaniaSerbiaSingaporeSlovakiaSloveniaSouth AfricaSouth KoreaSpainSwedenSwitzerlandTaiwanTurkeyUnited KingdomUnited StatesVietnamWorldwideOthers
Abcepta, Inc.
(888) 735-7227 / (858) 622-0099
(858) 622-0609
USA Headquarters
(888) 735-7227 / (858) 622-0099 or (858) 875-1900

Shipping Information

Domestic orders (in stock items)
Shipped out the same day. Orders placed after 1 PM (PST) will ship out the next business day.
International orders
Contact your local distributors
Terms & Conditions
"