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Lin28-TAT, Human Recombinant

CSDD1, LIN28A, ZCCHC1, Protein lin-28 homolog A, Zinc finger CCHC domain-containing protein 1

     
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Product info
Primary Accession Q9H9Z2
Calculated MW 24.4 kDa
Additional Info
Gene ID 79727
Other Names CSDD1, LIN28A, ZCCHC1, Protein lin-28 homolog A, Zinc finger CCHC domain-containing protein 1
Gene Source Human
Source E. coli
Assay&Purity SDS-PAGE;≥95%
Assay2&Purity2 HPLC;≥95%
Recombinant Yes
Sequence Full length human Lin28 with 13-residue C-terminal TAT peptide (GGYGRKKRRQRRR)
Target/Specificity Lin28-TAT
Application Notes Reconstitute in sterile deionized water to a concentration of 0.1-1.0 mg/ml. Do not vortex. Additional carrier protein (example 0.1% BSA) is recommended for long term storage.
Format Dry powder
Storage -80°C;Lyophilized powder
Citations (0)

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Background

Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression. Suppressor of microRNA (miRNA) biogenesis, including that of let-7, miR107, miR-143 and miR-200c. Specifically binds miRNA precursors (pre-miRNAs), recognizing an 5'-GGAG-3' motif found in pre-miRNA terminal loop, and recruits ZCCHC11/TUT4 uridylyltransferase. This results in the terminal uridylation of target pre-miRNAs. Uridylated pre-miRNAs fail to be processed by Dicer and undergo degradation. The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state by preventing let-7-mediated differentiation of embryonic stem cells.

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$ 165.00
$ 685.00
Cat# PBV11464r-20
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