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Human CellExp™ CD163, Human recombinant
CD163, M130
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q86VB7 |
|---|---|
| Calculated MW | This protein is fused with a 6× His tag at C-terminus and has a calculated MW of 110.4 kDa. The protein migrates as 135-140 kDa in SDS-PAGE due to glycosylation. |
| Gene ID | 9332 |
|---|---|
| Other Names | CD163, M130 |
| Gene Source | Human |
| Source | HEK 293 cells |
| Assay&Purity | SDS-PAGE;≥95% |
| Assay2&Purity2 | N/A;≥95% |
| Recombinant | Yes |
| Target/Specificity | CD163 |
| Application Notes | Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml |
| Format | Lyophilized |
| Storage | -20°C;Lyophilized from 0.22 µm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Scavenger receptor cysteine-rich type 1 protein M130 (CD163) is also known as hemoglobin scavenger receptor, which is a scavenger receptor for the hemoglobin-haptoglobin complex. CD163 has also been shown to mark cells of monocyte/macrophage lineage. A soluble form of the receptor exists in plasma, commonly denoted sCD163. sCD163 is generated by ectodomain shedding of the membrane bound receptor. sCD163 is upregulated in a large range of inflammatory diseases including liver cirrhosis, type 2 diabetes, macrophage activation syndrome, Gaucher’s disease, sepsis, HIV infection, rheumatoid arthritis and Hodgkin Lymphoma.
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