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Active Cathepsin D, Human Recombinant

Procathepsin D, CTSD

     
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Product info
Primary Accession P07339
Calculated MW 45.1 kDa
Additional Info
Gene ID 1509
Other Names Procathepsin D, CTSD
Gene Source Human
Source E. coli
Assay&Purity SDS-PAGE;≥80%
Assay2&Purity2 N/A;≥80%
Recombinant Yes
Target/Specificity Cathepsin D
Application Notes Reconstitute to 1 mg/ml in water
Format Freeze-Dried
Storage -20°C;Freeze-dried from proprietary buffer
Citations (0)

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Background

Cathepsin D is a lysosomal aspartyl protease composed of a protein dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is an estrogen-regulated protein associated with tissue breakdown. Levels of cathepsin D have been positively correlated with recurring breast cancers of both node negative and node positive types. Additionally cathepsin D has been associated with amyloid formation in Alzheimer’s plaques. Cathepsin D is produced initially as a pre-pro-enzyme which gets transported to lysosomes via endosomes in most cell types. In endosomes, it gets proteolyzed by unidentified proteases by removal of the pro-peptide to generate active single-chain Cathepsin D; while in lysosomes, further processing by cysteine cathepsins B and L generates mature, active double-chain Cathepsin D. BioVision’s Active Human Cathepsin D is a proteolytically active, non-glycosylated enzyme expressed, purified and activated by proprietary methods.

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Cat# PBV11473r-10
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