Human CellExp™ Human CD40/ TNFRSF5, Human recombinant
CD40, Bp50, CDW40, MGC9013, TNFRSF5, p50
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | AAH12419.1 |
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Calculated MW | This protein is fused with a 6× His tag at C-terminus and has a calculated MW of 20 kDa. The protein migrates as 32 kDa in SDS-PAGE due to glycosylation. |
Other Names | CD40, Bp50, CDW40, MGC9013, TNFRSF5, p50 |
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Gene Source | Human |
Source | HEK 293 cells |
Assay&Purity | SDS-PAGE;>95% |
Assay2&Purity2 | N/A;>95% |
Recombinant | Yes |
Target/Specificity | CD40 |
Application Notes | Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml |
Format | Lyophilized |
Storage | -20°C;Lyophilized from 0.22 µm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Tumor necrosis factor receptor superfamily member 5 (TNFRSF5) is also known as CD40, is a member of the TNF receptor superfamily. The expression of CD40 is diverse. TNFRSF5 has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 is the receptor for TNFSF5/CD40LG. Defects in CD40 are the cause of immunodeficiency with hyper-IgM type 3 (HIGM3).
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