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Human CellExp™ CD28, Human recombinant
CD28, Tp44
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | AAH93698 |
|---|---|
| Calculated MW | This protein is fused with a Fc tag at C-terminus and has a calculated MW of 41.8 kDa. |
| Other Names | CD28, Tp44 |
|---|---|
| Gene Source | Human |
| Source | HEK 293 cells |
| Assay&Purity | SDS-PAGE;≥92% |
| Assay2&Purity2 | N/A;≥92% |
| Recombinant | Yes |
| Target/Specificity | CD28 |
| Application Notes | Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml |
| Format | Lyophilized |
| Storage | -20°C;Lyophilized |
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Provided below are standard protocols that you may find useful for product applications.
Background
T-cell-specific surface glycoprotein CD28 is also known as TP44, is a single-pass type I membrane protein which contains one Ig-like V-type (immunoglobulin-like) domain. is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2). When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells.
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