|Calculated MW||This protein is fused with a Fc tag at C-terminus and has a calculated MW of 40.4 kDa.|
|Other Names||ICOS, CD278, AILIM|
|Source||HEK 293 cells|
|Application Notes||Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml|
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Provided below are standard protocols that you may find useful for product applications.
Inducible T-cell costimulator (ICOS) is also known as Activation-inducible lymphocyte immunomediatory molecule (AILIM), CD278, which belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. ICOS enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. CD278 / ICOS prevents the apoptosis of pre-activated T-cells and also plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
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