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Human CellExp™ ICOS / CD278, Human recombinant

ICOS, CD278, AILIM

     
  • SPECIFICATION
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Product info
Primary Accession NP_036224
Calculated MW This protein is fused with a Fc tag at C-terminus and has a calculated MW of 40.4 kDa.
Additional Info
Other Names ICOS, CD278, AILIM
Gene Source Human
Source HEK 293 cells
Recombinant Yes
Target/Specificity CD278
Application Notes Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml
Format Lyophilized
Storage -20°C;Lyophilized
Citations (0)

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Background

Inducible T-cell costimulator (ICOS) is also known as Activation-inducible lymphocyte immunomediatory molecule (AILIM), CD278, which belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. ICOS enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. CD278 / ICOS prevents the apoptosis of pre-activated T-cells and also plays a critical role in CD40-mediated class switching of immunoglobin isotypes.

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$ 150.00
$ 590.00
Cat# PBV11482r-10
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