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Human CellExp™ ICOS / CD278, Human recombinant
ICOS, CD278, AILIM
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | NP_036224 |
|---|---|
| Calculated MW | This protein is fused with a Fc tag at C-terminus and has a calculated MW of 40.4 kDa. |
| Other Names | ICOS, CD278, AILIM |
|---|---|
| Gene Source | Human |
| Source | HEK 293 cells |
| Recombinant | Yes |
| Target/Specificity | CD278 |
| Application Notes | Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml |
| Format | Lyophilized |
| Storage | -20°C;Lyophilized |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Inducible T-cell costimulator (ICOS) is also known as Activation-inducible lymphocyte immunomediatory molecule (AILIM), CD278, which belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. ICOS enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. CD278 / ICOS prevents the apoptosis of pre-activated T-cells and also plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
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