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Human CellExp™ B7-H3 / CD276, Human recombinant
B7-H3, CD276, B7 homolog 3
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q5ZPR3-2 |
|---|---|
| Calculated MW | This protein is fused with a Fc tag at C-terminus and has a calculated MW of 50 kDa. |
| Other Names | B7-H3, CD276, B7 homolog 3 |
|---|---|
| Gene Source | Human |
| Source | HEK 293 cells |
| Assay&Purity | SDS-PAGE;>95% |
| Assay2&Purity2 | N/A;>95% |
| Recombinant | Yes |
| Target/Specificity | CD276 |
| Application Notes | Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml |
| Format | Lyophilized |
| Storage | -20°C;Lyophilized |
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Provided below are standard protocols that you may find useful for product applications.
Background
B7 homolog 3 (B7-H3), a member of the immunoglobulin superfamily, is also known CD276, which contains two Ig-like C2-type (immunoglobulin-like) domains and two Ig-like V-type (immunoglobulin-like) domains. B7-H3 may participate in the regulation of T-cell-mediated immune response. B7-H3 also plays a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. Furthermore, B7-H3 is involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. It could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy.
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