Human CellExp™ CD38, human recombinant
ADP-ribosyl Cyclase 1, Cyclic ADP-ribose Hydrolase 1, ADPRC 1, T10
|Calculated MW||70 kDa|
|Other Names||ADP-ribosyl Cyclase 1, Cyclic ADP-ribose Hydrolase 1, ADPRC 1, T10|
|Source||HEK 293 cells|
|Application Notes||Reconstitute in 1X PBS to the desired protein concentration.|
|Storage||-20°C;Lyophilized from 0.2 µm-filtered solution in PBS.|
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CD38, also known as cyclic ADP ribose hydrolase is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B lymphocytes and natural killer cells. CD38 also functions in cell adhesion, signal transduction and calcium signaling. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. These reaction products are essential for the regulation of intracellular Ca2+. The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications including social amnesia possibly related to autism. The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism, as well as some genetically determined conditions.
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