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Human CellExp™ LYVE-1, mouse recombinant

Lymphatic Vessel Endothelial Hyaluronan (HA) Receptor-1, Xlkd1, Lyve-1, Crsbp-1

     
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Product info
Primary Accession Q8BHC0 
Calculated MW 70 kDa
Additional Info
Other Names Lymphatic Vessel Endothelial Hyaluronan (HA) Receptor-1, Xlkd1, Lyve-1, Crsbp-1
Gene Source Mouse
Source HEK 293 cells
Assay&Purity SDS-PAGE;≥ 98%
Recombinant Yes
Target/Specificity Lyve1
Application Notes Reconstitute in 1X PBS to the desired protein concentration.
Format Lyophilized
Storage -20°C;Lyophilized from 0.2 µm-filtered solution in PBS.
Citations (0)

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Background

Lymphatic Vessel Endothelial Hyaluronan (HA) Receptor-1 (LYVE-1) is a 60-kDa type I transmembrane glycoprotein that is a member of the Link Protein superfamily. HA is found in the extracellular matrix of most animal tissues and in body fluids. It modulates cell behavior and functions during tissue remodeling, development, homeostasis, and disease. It is often used as a marker of lymphatic endothelia. LYVE-1 is expressed on both the lumenal and ablumenal surfaces of lymphatic endothelium, and also on hepatic blood sinusoidal endothelia. This expression pattern, combined with studies showing that LYVE-1 can support cellular HA internalization in vitro, may suggest LYVE-1 participation in HA internalization for degradation, or transport of HA from tissues into the lumen of lymphatic vessels. LYVE-1-directed HA localization to lymphatic surfaces might also affect aspects of the immune response or tumor metastases. HA binding to CD44 can still occur in the presence of LYVE-1 in vitro. Therefore, LYVE-1-directed HA localization to lymphatics could provide a substrate for transmigrating CD44+ leukocytes or tumor cells. In addition to hepatic and lymphatic endothelia, some expression of LYVE-1 has been reported on Kupffer cells, the islets of Langerhans, cortical neurons, and renal epithelium.

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$ 185.00
$ 375.00
Cat# PBV11494r-10
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