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Human CellExp™ VSIG4, human recombinant
V-set and immunoglobulin domain containing 4; Z39Ig; CRIg
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9Y279 |
|---|---|
| Calculated MW | 68 kDa |
| Gene ID | 11326 |
|---|---|
| Other Names | V-set and immunoglobulin domain containing 4; Z39Ig; CRIg |
| Gene Source | Human |
| Source | HEK 293 cells |
| Assay&Purity | SDS-PAGE;≥ 98% |
| Recombinant | Yes |
| Target/Specificity | VSIG4 |
| Application Notes | Reconstitute in 1X PBS to the desired protein concentration. |
| Format | Lyophilized |
| Storage | -20°C;Lyophilized from 0.2 µm-filtered solution in PBS. |
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Provided below are standard protocols that you may find useful for product applications.
Background
VSIG4 (V-set and immunoglobulin domain containing 4), as known as complement receptor of the immunoglobulin superfamily (CRIg) and Z39Ig. It is a B7 family-related protein and an Ig superfamily member. In contrast to the B7 family members which contain two IgG domains, VSIG4 contains one complete V-type I g domain and a truncated C-type I g domain. VSIG4 is exclusively expressed on tissue resident macrophages and binds to multimers of C3b and iC3b that are covalently attached to particle surfaces. VSIG4 functions as a negative regulator of T cell activation, and may be involved in the maintenance of peripheral T cell tolerance, and is also identified as a potent suppressor of established inflammation.
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