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Maspin, human recombinant
Serpin B5, PI-5
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P36952 |
|---|---|
| Calculated MW | 42.1 kDa |
| Gene ID | 5268 |
|---|---|
| Other Names | Serpin B5, PI-5 |
| Gene Source | Human |
| Source | E. coli |
| Assay&Purity | SDS-PAGE;> 95% |
| Assay2&Purity2 | HPLC;> 95% |
| Recombinant | Yes |
| Sequence | MDALQLANSA FAVDLFKQLC EKEPLGNVLF SPICLSTSLS LAQVGAKGDT ANEIGQVLHF ENVKDIPFGF QTVTSDVNKL SSFYSLKLIK RLYVDKSLNL STEFISSTKR PYAKELETVD FKDKLEETKG QINNSIKDLT DGHFENILAD NSVNDQTKIL VVNAAYFVGK WMKKFPESET KECPFRLNKT DTKPVQMMNM EATFCMGNID SINCKIIELP FQNKHLSMFI LLPKDVEDES TGLEKIEKQL NSESLSQWTN PSTMANAKVK LSIPKFKVEK MIDPKACLEN LGLKHIFSED TSDFSGMSET KGVALSNVIH KVCLEITEDG GDSIEVPGAR ILQHKDELNA DHPFIYIIRH NKTRNIIFFG KFCSP |
| Target/Specificity | SERPINB5 |
| Application Notes | Reconstituted in ddH2O at 100 µg/mL. |
| Format | Lyophilized |
| Storage | -20°C;Lyophilized after extensive dialysis against PBS. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Maspin is a non-inhibitory member of the serpin superfamily, a group of 40-60 kDa serine protease inhibitors. Maspin was discovered in 1994 and has been identified in prostate, thymus, testis, intestine, tongue, and lung. Recently Maspin received a great deal of attention due to its potential apoptotic role in cancers. Maspin expression predicts a better prognosis for several types of carcinomas including breast, prostate, colon, and oral squamus cell carcinoma. The level of Maspin is also inversely correlated to VEGF-A, an angiogenic factor. Researchers found that Maspin may play its apoptotic role as an endogenous inhibitor of histone deacetylase I (HDAC I). Therefore, Maspin is a potential personalized marker of Non-Small Cell Lung Carcinoma (NSCLC).
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