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Human CellExp™ Frizzled-2 / FZD2 Protein, Human recombinant
FZD2, Frizzled-2, Fz-2, hFz2, FzE2
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q14332 |
|---|---|
| Calculated MW | 41.7 kDa |
| Gene ID | 2535 |
|---|---|
| Other Names | FZD2, Frizzled-2, Fz-2, hFz2, FzE2 |
| Gene Source | Human |
| Source | HEK 293 cells |
| Assay&Purity | SDS-PAGE;> 95% |
| Recombinant | Yes |
| Target/Specificity | FZD2 |
| Application Notes | Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. |
| Format | Lyophilized |
| Storage | -80°C;Lyophilized from 0.22 µm filtered solution in 50 mM tris, 100 mM glycine, pH 7.5. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Frizzled-2 (FZD2) is also known as FzE2, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD2 contains one FZ (frizzled) domain. FZD2 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. The Lys-Thr-X-X-X-Trp motif of FZD2 interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
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