Human CellExp™ Frizzled-4 / FZD4 Protein, Human recombinant
FZD4, Frizzled-4, CD344, Fz-4, hFz4, FzE4
|Calculated MW||42.9 kDa|
|Other Names||FZD4, Frizzled-4, CD344, Fz-4, hFz4, FzE4|
|Source||HEK 293 cells|
|Application Notes||Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex.|
|Storage||-80°C;Lyophilized from 0.22 µm filtered solution in PBS pH 7.5. Generally Mannitol or Trehalose is added as a protectant before lyophilization.|
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Provided below are standard protocols that you may find useful for product applications.
Frizzled-4 (FZD4) is also known as FzE4, CD344, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD4 contains one FZ (frizzled) domain. FZD4 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. FZD4 interacts with MAGI3 and norrin (NDP).
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