BAIAP2, Human recombinant
Brain-specific angiogenesis inhibitor 1-associated protein 2, BAI1-associated protein 2, Protein BAP
|Calculated MW||58.4 kDa|
|Other Names||Brain-specific angiogenesis inhibitor 1-associated protein 2, BAI1-associated protein 2, Protein BAP2, Fas ligand-associated factor 3, Insulin receptor substrate p53/p58, Insulin receptor substrate protein of 53kDa, FLAF3, IRS-58, IRSp53/58, IRSP53.|
|Application Notes||Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex.|
|Storage||-80°C;In 20mM Tris-HCl buffer (pH 8.0), 0.1 M NaCl, 1mM DTT and 30% glycerol.|
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BAIAP2 is a ubiquitous regulator of the actin cytoskeleton. Controlled by the Rho-family GTPases BAIAP2 facilitates filopodia development. BAIAP2 is expressed in the cytoplasm and binds small membrane-bound G-proteins to cytoplasmic effector proteins and operates as an insulin receptor tyrosine kinase substrate. BAIAP2 proposes a part for insulin in the central nervous system and was identified as interacting with the dentatorubral pallidoluysian atrophy gene, which is related to an autosomal dominant neurodegenerative disease.
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