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Biotinylated PD-1/PDCD1, Human Recombinant
PDCD1, PD1, CD279, SLEB2, hPD-1, hPD-l
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q15116 |
|---|---|
| Calculated MW | 19.7 kDa |
| Gene ID | 5133 |
|---|---|
| Other Names | PDCD1, PD1, CD279, SLEB2, hPD-1, hPD-l |
| Gene Source | Human |
| Source | E. coli |
| Assay&Purity | SDS-PAGE;> 90% |
| Assay2&Purity2 | SEC;> 90% |
| Recombinant | Yes |
| Target/Specificity | PD1 |
| Format | Liquid |
| Storage | -20°C;0.5 mg/ml solution in in PBS containing 20% glycerol |
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Provided below are standard protocols that you may find useful for product applications.
Background
Programmed death protein 1 (PD-1) is also known as CD279 and PDCD1, is a type I membrane protein and is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 is expressed on the surface of activated T cells, B cells, macrophages, myeloid cells and a subset of thymocytes. PD-1 has two ligands, PD-L1 and PD-L2, which are members of the B7 family. PD-L1 is expressed on almost all murine tumor cell lines, including PA1 myeloma, P815 mastocytoma, and B16 melanoma upon treatment with IFN-γ. PD-L2 expression is more restricted and is expressed mainly by DCs and a few tumor lines. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. In vitro, treatment of anti-CD3 stimulated T cells with PD-L1-Ig results in reduced T cell proliferation and IFN-γ secretion. Monoclonal antibodies targeting PD-1 that boost the immune system are being developed for the treatment of cancer. This protein is suitable for use in protein studies such as protein structure analysis and protein-protein interactions. It can also be used as an immunogen, as a protein standard, or in cell biology research applications.
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