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NT5C3B, human recombinant
NT5C3L, 7-methylguanosine phosphate-specific 5'-nucleotidase
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q969T7 |
|---|---|
| Calculated MW | 36.8 kDa |
| Gene ID | 115024 |
|---|---|
| Other Names | NT5C3L, 7-methylguanosine phosphate-specific 5'-nucleotidase |
| Gene Source | Human |
| Source | E. coli |
| Assay&Purity | SDS-PAGE;> 85% |
| Recombinant | Yes |
| Sequence | MGSSHHHHHH SSGLVPRGSH MGSMAEEVST LMKATVLMRQ PGRVQEIVGA LRKGGGDRLQ VISDFDMTLS RFAYNGKRCP SSYNILDNSKIISEECRKEL TALLHHYYPI EIDPHRTVKE KLPHMVEWWT KAHNLLCQQK IQKFQIAQVV RESNAMLREG YKTFFNTLYH NNIPLFIFSAGIGDILEEII RQMKVFHPNI HIVSNYMDFN EDGFLQGFKG QLIHTYNKNS SACENSGYFQ QLEGKTNVIL LGDSIGDLTM ADGVPGVQNILKIGFLNDKV EERRERYMDS YDIVLEKDET LDVVNGLLQH ILCQGVQLEM QGP |
| Target/Specificity | NT5C3B |
| Format | Liquid |
| Storage | -20°C;Phosphate Buffered Saline (pH7.4) containing 20% glycerol, 1mM DTT |
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Provided below are standard protocols that you may find useful for product applications.
Background
NT5C3B, also known 7-methylguanosine phosphate-specific 5'-nucleotidase, includes transferase activity and nucleotide binding. Among its related super-pathways are adenosine nucleotides degradation II and Pyrimidine metabolism. Specifically it hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7- methylguanosine and inorganic phosphate. The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids. Also it has weak activity for CMP. Recombinant human NT5C3B protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography
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