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Carbonic anhydrase-8, human recombinant
CA-VIII, CALS, CAMRQ3, CARP, CA8
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P35219 |
|---|---|
| Calculated MW | 35.5 kDa |
| Gene ID | 767 |
|---|---|
| Other Names | CA-VIII, CALS, CAMRQ3, CARP, CA8 |
| Gene Source | Human |
| Source | E. coli |
| Assay&Purity | SDS-PAGE;> 90% |
| Recombinant | Yes |
| Sequence | MGSSHHHHHH SSGLVPRGSH MGSHMADLSF IEDTVAFPEK EEDEEEEEEG VEWGYEEGVE WGLVFPDANG EYQSPINLNS REARYDPSLL DVRLSPNYVV CRDCEVTNDG HTIQVILKSK SVLSGGPLPQ GHEFELYEVR FHWGRENQRG SEHTVNFKAF PMELHLIHWN STLFGSIDEA VGKPHGIAII ALFVQIGKEH VGLKAVTEIL QDIQYKGKSK TIPCFNPNTL LPDPLLRDYW VYEGSLTIPP CSEGVTWILF RYPLTISQLQ IEEFRRLRTH VKGAELVEGC DGILGDNFRP TQPLSDRVIR AAFQ |
| Target/Specificity | CA8 |
| Format | Liquid |
| Storage | -20°C;In 20 mM Tris-HCl buffer (pH8.0) containing 1mM DTT, 20% glycerol |
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Provided below are standard protocols that you may find useful for product applications.
Background
CA8 was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, this protein lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). It continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. Defects in CA8 are the cause of cerebellar ataxia mental retardation and dysequilibrium syndrome type 3 (CMARQ3). Recombinant human CA8 protein fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
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