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Thymosin alpha 1
Prothymosin alpha, PTMA, TMSA
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P06454 |
|---|---|
| Calculated MW | 3.1 kDa |
| Gene ID | 5757 |
|---|---|
| Other Names | Prothymosin alpha, PTMA, TMSA |
| Gene Source | Human |
| Source | N/A |
| Assay&Purity | HPLC;> 99% |
| Recombinant | No |
| Target/Specificity | PTMA |
| Application Notes | Reconstitute in Trifluoro acetic acid |
| Format | Lyophilized |
| Storage | -20°C;N/A |
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Provided below are standard protocols that you may find useful for product applications.
Background
Thymosin α1 is a peptide fragment derived from prothymosin alpha, a protein that in humans is encoded by the PTMA gene. Thymosin α1 is believed to be a major component of Thymosin Fraction 5 responsible for the activity of that preparation in restoring immune function in animals lacking thymus glands. It was the first of the peptides from Thymosin Fraction 5 to be completely sequenced and synthesized. Unlike β thymosins, to which it is genetically and chemically unrelated, thymosin α1 is produced as a 28-amino acid fragment, from a longer, 113-amino acid precursor, prothymosin α. It has been found to enhance cell-mediated immunity in humans as well as experimental animals.
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