Isocitrate Dehydrogenase 1 R132H mutant, Recombinant Human
Isocitrate dehydrogenase [NADP] cytoplasmic, R132H, IDH 1 R132H
|Calculated MW||50.9 kDa|
|Other Names||Isocitrate dehydrogenase [NADP] cytoplasmic, R132H, IDH 1 R132H|
|Application Notes||Reconstitute in deionized water to the final concentration 0.5 mg/ml and incubate the reconstituted protein at 25 °C for 15 minutes.|
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Provided below are standard protocols that you may find useful for product applications.
Mutations of the cytosolic IDH 1 are a common feature in primary human brain cancers. Arginine 132 (R132) of IDH is highly conserved among different isoforms of IDH and is most commonly mutated to Histidine. Mutation of IDH1 R132H leads to accumulation of R(-)-2-hydroxyglutarate (2HG), which correlates with an increased risk for malignant brain tumors.
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