Glyoxalase II (Glx II), Human Recombinant
Hydroxyacylglutathione hydrolase, mitochondrial, HAGH1, GLO2
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q16775 |
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Calculated MW | 32.4 kDa |
Gene ID | 3029 |
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Other Names | Hydroxyacylglutathione hydrolase, mitochondrial, HAGH1, GLO2 |
Gene Source | Human |
Source | E. coli |
Assay&Purity | SDS-PAGE;≥90% |
Recombinant | Yes |
Target/Specificity | HAGH |
Format | Liquid |
Storage | -20°C;30% glycerol, 50 mM Tris pH 7.4 and 150 mM NaCl |
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Provided below are standard protocols that you may find useful for product applications.
Background
The glyoxalase system consists of Glyoxalase I (Glx I) and Glyoxalase II (Glx II) which is responsible for detoxifying α-ketoaldehydes such as the potent and cytotoxic methylglyoxal (MG). Glx I converts MG to S-D-lactoyl-glutathione (SLG). SLG is then hydrolyzed to D-lactate and reduced glutathione by Glx II. Glx II desensitizes cells to p53-dependent DNA damage-induced apoptosis. It also plays a role during development and in the pathogenesis of cancer and neurodegenerative diseases. Glyoxalase II may also be important in the regulation of spermatogenesis.
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