Human CellExp™ Gremlin / GREM1, Fc Tag, Human recombinant
GREM1, CKTSF1B1, DAND2, DRM, PIG2
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O70326 |
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Calculated MW | 44.2 kDa |
Gene ID | 23892 |
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Other Names | GREM1, CKTSF1B1, DAND2, DRM, PIG2 |
Gene Source | Human |
Source | HEK 293 cells |
Assay&Purity | SDS-PAGE;> 95% |
Recombinant | Yes |
Target/Specificity | Grem1 |
Application Notes | Reconstitute in sterile deionized water to the desired protein concentration. |
Format | Lyophilized |
Storage | -20°C;Lyophilized from 0.22 µm filtered solution in PBS, pH7.4. Normally Trehalose is added as protectant before lyophilization. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Gremlin is also known as Cysteine knot superfamily 1, BMP antagonist 1 (CKTSF1B1), DAN domain family member 2 (DAND2), Down-regulated in Mos-transformed cells protein (DRM), Increased in high glucose protein 2 (IHG-2), Cell proliferation-inducing gene 2 protein (PIG2) or Gremlin-1 (GREM1), which is highly expressed in small intestine, fetal brain and colon. Gremlin / GREM-1 interacts with SLIT1 and SLIT2 in a glycosylation-dependent manner. Gremlin may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Gremlin down-regulates the BMP4 signaling in a dose-dependent manner and acts as inhibitor of monocyte chemotaxis.
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