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>   home   >   Products   >   Proteins   >   Human Inosine-5′-Monophosphate Dehydrogenase II, human recombinant    

Human Inosine-5′-Monophosphate Dehydrogenase II, human recombinant

IMP dehydrogenase type II, IMPDH II, IMPD2, IMPDH

     
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Product info
Primary Accession P12268
Calculated MW 57 kDa
Additional Info
Gene ID 3615
Other Names IMP dehydrogenase type II, IMPDH II, IMPD2, IMPDH
Gene Source Human
Source E.coli
Assay&Purity SDS-PAGE;> 90%
Recombinant Yes
Target/Specificity IMPDH2
Format Liquid
Storage -20°C;20 mM Tris, pH 8.0, 150 mM NaCl, 2mM DTT, 2mM EDTA and 20% glycerol
Citations (0)

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Background

Inosine monophosphate dehydrogenase, IMPDH, (E.C. 1.1.1.205) is the rate-limiting enzyme in de novo guanine nucleotide biosynthesis and it is essential for lymphocyte proliferation. IMPDH oxidizes inosine 5’-monophosphate (IMP) to xanthine 5’-monophosphate (XMP) using NAD as a cofactor. It plays a critical role in cell growth and in the malignancy of some tumors. IMPDH II is the predominant isoform of IMPDH and is specifically linked to a wide range of cancers and lymphocyte proliferation. BioVision’s active human IMPDH II is suitable for functional assays, high-throughput screening and preclinical studies in drug discovery.

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$ 195.00
$ 645.00
Cat# PBV11611r-20
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