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Human Inosine-5′-Monophosphate Dehydrogenase II, human recombinant
IMP dehydrogenase type II, IMPDH II, IMPD2, IMPDH
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P12268 |
|---|---|
| Calculated MW | 57 kDa |
| Gene ID | 3615 |
|---|---|
| Other Names | IMP dehydrogenase type II, IMPDH II, IMPD2, IMPDH |
| Gene Source | Human |
| Source | E.coli |
| Assay&Purity | SDS-PAGE;> 90% |
| Recombinant | Yes |
| Target/Specificity | IMPDH2 |
| Format | Liquid |
| Storage | -20°C;20 mM Tris, pH 8.0, 150 mM NaCl, 2mM DTT, 2mM EDTA and 20% glycerol |
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Provided below are standard protocols that you may find useful for product applications.
Background
Inosine monophosphate dehydrogenase, IMPDH, (E.C. 1.1.1.205) is the rate-limiting enzyme in de novo guanine nucleotide biosynthesis and it is essential for lymphocyte proliferation. IMPDH oxidizes inosine 5’-monophosphate (IMP) to xanthine 5’-monophosphate (XMP) using NAD as a cofactor. It plays a critical role in cell growth and in the malignancy of some tumors. IMPDH II is the predominant isoform of IMPDH and is specifically linked to a wide range of cancers and lymphocyte proliferation. BioVision’s active human IMPDH II is suitable for functional assays, high-throughput screening and preclinical studies in drug discovery.
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