Human Inosine-5′-Monophosphate Dehydrogenase II, human recombinant
IMP dehydrogenase type II, IMPDH II, IMPD2, IMPDH
|Calculated MW||57 kDa|
|Other Names||IMP dehydrogenase type II, IMPDH II, IMPD2, IMPDH|
|Storage||-20°C;20 mM Tris, pH 8.0, 150 mM NaCl, 2mM DTT, 2mM EDTA and 20% glycerol|
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Inosine monophosphate dehydrogenase, IMPDH, (E.C. 220.127.116.11) is the rate-limiting enzyme in de novo guanine nucleotide biosynthesis and it is essential for lymphocyte proliferation. IMPDH oxidizes inosine 5’-monophosphate (IMP) to xanthine 5’-monophosphate (XMP) using NAD as a cofactor. It plays a critical role in cell growth and in the malignancy of some tumors. IMPDH II is the predominant isoform of IMPDH and is specifically linked to a wide range of cancers and lymphocyte proliferation. BioVision’s active human IMPDH II is suitable for functional assays, high-throughput screening and preclinical studies in drug discovery.
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