|Precautions||Angiotensin III Protein is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Angiotensin III (Ang III) is a hexapeptide formed as a result of a cleavage at the N-terminus of Angiotensin II (Ang II)1,a key factor in the Renin-Angiotensin-Aldosterone (RAAS) system. In peripheral Ang systems, Ang II is the main effector peptide in the systemic circulation, although exogenous Ang III can be as potent as Ang II in, for example, stimulating aldosterone secretion2 or inhibiting renin release3. In the rat brain, Ang III was found to be equipotent with Ang II as a pressor agent or dipsogen4-7and was bound as avidly to the nervous system as Ang II. Ang receptor subtype AT1 has greater affinity towards Ang II and is also responsive to Ang III, while the AT2 receptor subtype appears to be more sensitive to Ang III but less responsive to Ang II1.
1 . Wright, JW. et al.(2011)Prog. Neurobiol.95,49.
2 . Blair-West, JR. et al.(1980)J. Endocrinol.87,409.
3 . Fei, DTW. et al.(1980)Life Sci.27,1495.
4 . Fink, GD. et al.(1985)Am. J. Physiol. Endocrinol. Metab.249,E201.
5 . Jensen, LL. et al.(1989)Brain Res.490,48.
6 . Wright, JW. et al.(1985)Am. J. Physiol.Regulatory Integrative Comp. Physiol.249,R514.
7 . Wright, JW. et al.(1989)Am. J. Physiol.Regulatory Integrative Comp. Physiol.257,R1551.
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