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Angiotensin III Protein

A Ligand of AT1 and AT2 G-Protein Coupled Receptors

  • WB - Angiotensin III Protein PG10011-025
    Angiotensin_III - Abgent Angiotensin III induces MAPK activation in IEC-6 cells similar to Angiotensin II.Cells were incubated in serum depleted medium for 2 h and then stimulated with 0.1 µM and 1 µM Angiotensin III (#PG10011) for 10 min or with 0.1 µM and 1 µM Angiotensin II for comparison. Cell proteins were resolved by SDS-PAGE and probed with anti-phospo-ERK1/2.
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PrecautionsAngiotensin III Protein is for research use only and not for use in diagnostic or therapeutic procedures.
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Angiotensin III (Ang III) is a hexapeptide formed as a result of a cleavage at the N-terminus of Angiotensin II (Ang II)1,a key factor in the Renin-Angiotensin-Aldosterone (RAAS) system. In peripheral Ang systems, Ang II is the main effector peptide in the systemic circulation, although exogenous Ang III can be as potent as Ang II in, for example, stimulating aldosterone secretion2 or inhibiting renin release3. In the rat brain, Ang III was found to be equipotent with Ang II as a pressor agent or dipsogen4-7and was bound as avidly to the nervous system as Ang II. Ang receptor subtype AT1 has greater affinity towards Ang II and is also responsive to Ang III, while the AT2 receptor subtype appears to be more sensitive to Ang III but less responsive to Ang II1.


1 . Wright, JW. et al.(2011)Prog. Neurobiol.95,49.
2 . Blair-West, JR. et al.(1980)J. Endocrinol.87,409.
3 . Fei, DTW. et al.(1980)Life Sci.27,1495.
4 . Fink, GD. et al.(1985)Am. J. Physiol. Endocrinol. Metab.249,E201.
5 . Jensen, LL. et al.(1989)Brain Res.490,48.
6 . Wright, JW. et al.(1985)Am. J. Physiol.Regulatory Integrative Comp. Physiol.249,R514.
7 . Wright, JW. et al.(1989)Am. J. Physiol.Regulatory Integrative Comp. Physiol.257,R1551.

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$ 88.80
$ 273.60
Cat# PG10011-025
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