|Precautions||Bombesin Protein is for research use only and not for use in diagnostic or therapeutic procedures.|
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Bombesin is an active neuropeptide originally isolated from amphibian skin but also found in the central and peripheral nervous system of amphibians1. Later it was established that mammals and birds express two family groups of endogenous Bombesin-like factors, the gastrin-releasing peptides and neuromedin B2. The biological activities of bombesin are mediated through a family of three specific G-protein coupled receptors (GPCRs): BB1which is also known as a neuromedin B receptor, BB2 also known as a gastrin-releasing peptide receptor and BB3 which is a low affinity binder for the Bombesin-like factors3,4.
Bombesin and Bombesin-like factors show a broad range of biological activities such as regulation of smooth muscle contraction, stimulation of neuropeptide and hormone secretion, modulation of neural activity, growth regulation, and mediate anorexic effects in the hypothalamus5.
1 . Anastasi, A. (1971) Naunyn. Schmiedebergs. Arch. Pharmakol.269,135.
2 . Battey, J. and Wada, E. (1991) Trends Neurosci. 14,524.
3 . Ohki-Hamazaki, H. et al.(2005)Int. J. Dev. Biol. 49,293.
4 . Wada E. et al. (1991)Neuron6,421.)
5 . Moody, T. W. and Merali, Z. (2004) Peptides25,511.
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