|Precautions||Bradykinin Protein is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Bradykinin is a potent effector peptide that binds the bradykinin receptors B2. Bradykinin reduces blood pressure and increases vascular permeability by inducing smooth muscle relaxation and blood vessel dilation1.
Bradykinin is one the most potent known factors inducing pain substances that acts on afferent sensory neurons Bradykinin stimulates the synthesis of prostaglandins2 and is a major contributor to the innate inflammatory response3. Injection of Bradykinin into the skin produces all the inflammation basic signs4. Bradykinin has been implicated also in various shock syndromes5. Application of Bradykinin to the central nervous system appears to initiate events leading to neural tissue damage as well as long lasting disturbances affecting blood-brain barrier function6.
1 . Bhoola, K.D. et al. (1992) Pharmacol. Rev.44,1.
2 . Brechter, A.B. and Lemel, U. H. (2007) Arthritis Rheum.56,910.
3 . Joseph, K. and Kaplan, A. P. 2005 Adv. Immunol.86,159.
4 . Marceau, F. et al. (1983) Gen. Pharmacol.14,209.
5 . Shin, Y. H. et al. (1996)Immunopharmacology 33,369.
6 . Walker, K. et al.(1995)Neurochem. Int.26,1.
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