|Precautions||Neurotensin Protein is for research use only and not for use in diagnostic or therapeutic procedures.|
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Neurotensin is a peptide neurotransmitter hormone produced from a 170 amino acid precursor protein, first isolated in 1973 from bovine hypothalamus1. Neurotensin signaling is transmitted through three receptors, NTS1 and NTS2 are 7-transmembrane G-protein coupled receptors, and NTS3 is a type I membrane receptor with a large extra cellular domain2.
Neurotensin synaptic transmission is terminated primarily by specific enzymatic cleavage of neurotensin by several peptidases3. Neurotensin participates in the regulation of Hypophyseal Prolactin and Luteinizing Hormone (LH) secretion4 and has a pivotal role in the dopaminergic system regulation5.
Neurotensin is implicated in body temperature regulation, feeding behavior, locomotion regulation6 and pain transmission7.
GPCR ligands are now part of our growing portfolio of GPCR related products, which also includes antibodies.
1 . Kislauskis, E. et al.(1988) J. Biol. Chem. 263,4963.
2 . Vincent, J.P. et al.(1999)Trends Pharmacol. Sci.20,302.
3 . Almenoff, J. et al.(1981) Biochem. Biophys. Res. Commun. 102,206.
4 . McCann, S.M. and Vijayan, E. (1992) Annals of the New York Academy of Sciences. 668,287.
5 . Elisabeth, B. et al.(2001)Pharmacol. Rev.53,453.
6 . Binder, E.B. et al.(2001)Pharmacol. Rev.53,453.
7 . Maeno, H. et al.(2004)Brain Res.998,122.
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