|Precautions||hArtemin Protein is for research use only and not for use in diagnostic or therapeutic procedures.|
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Artemin (ART), also named enovin and neublastin, is a neurotrophic factor that is crucial for the proper development of the sympathetic nervous system. ART belongs to the glial cell line-derived neurotrophic factor ( GDNF ) family of ligands, which also includes GDNF, neurturin (NRTN), and persephin (PSPN). Artemin mRNA is expressed in many human adult and fetal tissues and in rat Schwann cells. Artemin’s activity is mediated by a receptor complex composed of a receptor tyrosine kinase signaling component, RET , which is common for all GFLs, and a specific anchored membrane protein, GFRα3. Experimental studies have suggested that artemin supports the survival of cultured neurons from the dorsal root, trigeminal, nodose, and superior cervical ganglia and that it affects neurite outgrowth from the dorsal root and sympathetic ganglia of murine embryos. Recent investigations have reported that systemic artemin prevents and reverses neuropathic pain1.
1 . Lucini, C.et al. (2004) Anat. Embryol.208,403.
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