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ADWX-1 Protein
A Blocker KV1.3 K+Channels
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Storage | -20°C |
|---|---|
| Precautions | ADWX-1 Protein is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
KV1.3 channel is an attractive pharmacological target for immunomodulation of T cell-mediated autoimmune diseases. ADWX-1 peptide is a potent and selective KV1.3 channel blocker. ADWX-1 peptide is a synthetic analog of the scorpion peptide BmKTx. This peptide is based on the natural BmKTX in which three important residues were mutated in a structure-modification strategy to enhance the KV1.3 channel selectivity1. ADWX-1 inhibits KV1.3 channels heterologously expressed in HEK-293 cells. ADWX-1 blocks KV1.3 currents with an IC50 of 0.0019 nM and displays specificity for KV1.3 over KV1.1 and KV1.2 (IC50 values are 0.65 nM).
ADWX-1 inhibits CD4+ CCR7- T-cell proliferation.
ADWX-1 is an interesting therapeutic candidate to treat auto-immune disorders such as multiple sclerosis, type-1 diabetes, rheumatoid arthritis and psoriasis. This peptide is a valuable tool for studying the structure-function of KV1.3 channel and auto-immunity pathways2.
References
1 . Han, S.et al. (2008) J. Biol. Chem.283,19058.
2 . Li, Z. et al. (2012) J. Biol. Chem.287,29479.
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