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ABCB1 predesign siRNASynthetic RNA
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| RI10011 | 5 OD 400 ul | 13-15 days | $ 110.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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ABCB1 predesign siRNA - Additional info | |
| Gene ID | 5243 |
| Gene Symbol | ABCB1 |
| Other Names CLCS, MDR1, P-GP, PGY1, ABC20, CD243, GP170, MGC163296, ABCB1 | |
| Format HPLC purified siRNA is supplied as a dried pellet in nmol quantities. | |
| Storage Maintain refrigerated at 2-8°C for up to one week. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
ABCB1 predesign siRNA - Related products
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BACKGROUND
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
REFERENCES
Promoter methylation status of multidrug resistance 1 (MDR1) gene in noncancerous gastric mucosa correlates with Helicobacter Pylori infection and gastric cancer occurrence. Tahara T, et al. Cancer Invest, 2010 Aug. PMID 20636108. Interaction between ABCB1 and professional exposure to organochlorine insecticides in Parkinson disease. Dutheil F, et al. Arch Neurol, 2010 Jun. PMID 20558393. ABCB1/MDR1 gene polymorphisms as a prognostic factor in colorectal cancer. Balcerczak E, et al. Int J Colorectal Dis, 2010 Oct. PMID 20533057. Polymorphisms in the multiple drug resistance protein 1 and in P-glycoprotein 1 are associated with time to event outcomes in patients with advanced multiple myeloma treated with bortezomib and pegylated liposomal doxorubicin. Buda G, et al. Ann Hematol, 2010 Jun 8. PMID 20532504. Effect of host genetics on incidence of HIV neuroretinal disorder in patients with AIDS. Sezgin E, et al. J Acquir Immune Defic Syndr, 2010 Aug 1. PMID 20531015.
