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ABCB11 predesign siRNASynthetic RNA
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| RI10013 | 5 OD 400 ul | 13-15 days | $ 110.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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ABCB11 predesign siRNA - Additional info | |
| Gene ID | 8647 |
| Gene Symbol | ABCB11 |
| Other Names BSEP, PGY4, SPGP, ABC16, BRIC2, PFIC2, PFIC-2, ABCB11 | |
| Format HPLC purified siRNA is supplied as a dried pellet in nmol quantities. | |
| Storage Maintain refrigerated at 2-8°C for up to one week. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
ABCB11 predesign siRNA - Related products
AP6110a: ABCB11 Antibody (C-term)
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BACKGROUND
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy.
REFERENCES
A Large-scale genetic association study of esophageal adenocarcinoma risk. Liu CY, et al. Carcinogenesis, 2010 Jul. PMID 20453000. DHPLC screening for mutations in progressive familial intrahepatic cholestasis patients. Shapiro R, et al. J Hum Genet, 2010 May. PMID 20414253. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614. ATP8B1 and ABCB11 analysis in 62 children with normal gamma-glutamyl transferase progressive familial intrahepatic cholestasis (PFIC): phenotypic differences between PFIC1 and PFIC2 and natural history. Davit-Spraul A, et al. Hepatology, 2010 May. PMID 20232290. Role of common canalicular transporter gene variations in aetiology of idiopathic gallstones in childhood. Bronsk? J, et al. Folia Biol (Praha), 2010. PMID 20163776.
