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ABCB4 predesign siRNASynthetic RNA
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| RI10014 | 5 OD 400 ul | 13-15 days | $ 110.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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ABCB4 predesign siRNA - Additional info | |
| Gene ID | 5244 |
| Gene Symbol | ABCB4 |
| Other Names GBD1, MDR2, MDR3, PGY3, ABC21, MDR2/3, PFIC-3, ABCB4 | |
| Format HPLC purified siRNA is supplied as a dried pellet in nmol quantities. | |
| Storage Maintain refrigerated at 2-8°C for up to one week. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
ABCB4 predesign siRNA - Related products
AP6112a: ABCB4 Antibody (Center)
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BACKGROUND
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function.
REFERENCES
A Large-scale genetic association study of esophageal adenocarcinoma risk. Liu CY, et al. Carcinogenesis, 2010 Jul. PMID 20453000. The spectrum of liver diseases related to ABCB4 gene mutations: pathophysiology and clinical aspects. Davit-Spraul A, et al. Semin Liver Dis, 2010 May. PMID 20422496. DHPLC screening for mutations in progressive familial intrahepatic cholestasis patients. Shapiro R, et al. J Hum Genet, 2010 May. PMID 20414253. Role of common canalicular transporter gene variations in aetiology of idiopathic gallstones in childhood. Bronsk? J, et al. Folia Biol (Praha), 2010. PMID 20163776. Multidrug resistance protein 3 R652G may reduce susceptibility to idiopathic infant cholestasis. Chen XQ, et al. World J Gastroenterol, 2009 Dec 14. PMID 19998509.
