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ABCB6 predesign siRNASynthetic RNA
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| RI10016 | 5 OD 400 ul | 13-15 days | $ 110.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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ABCB6 predesign siRNA - Additional info | |
| Gene ID | 10058 |
| Gene Symbol | ABCB6 |
| Other Names ABC, PRP, umat, ABC14, MTABC3, EST45597, FLJ22414, ABCB6 | |
| Format HPLC purified siRNA is supplied as a dried pellet in nmol quantities. | |
| Storage Maintain refrigerated at 2-8°C for up to one week. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
ABCB6 predesign siRNA - Related products
AP6113a: ABCB6 Antibody (C-term)
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BACKGROUND
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This half-transporter likely plays a role in mitochondrial function. Localized to 2q26, this gene is considered a candidate gene for lethal neonatal metabolic syndrome, a disorder of mitochondrial function.
REFERENCES
Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. Saito A, et al. J Hum Genet, 2009 Jun. PMID 19343046. Human ABC transporter isoform B6 (ABCB6) localizes primarily in the Golgi apparatus. Tsuchida M, et al. Biochem Biophys Res Commun, 2008 May 2. PMID 18279659. Human ABCB6 localizes to both the outer mitochondrial membrane and the plasma membrane. Paterson JK, et al. Biochemistry, 2007 Aug 21. PMID 17661442. Identification of a mammalian mitochondrial porphyrin transporter. Krishnamurthy PC, et al. Nature, 2006 Oct 5. PMID 17006453. Heteronuclear multidimensional NMR and homology modelling studies of the C-terminal nucleotide-binding domain of the human mitochondrial ABC transporter ABCB6. Kurashima-Ito K, et al. J Biomol NMR, 2006 May. PMID 16791740.
