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ABCC6 predesign siRNASynthetic RNA
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| RI10024 | 5 OD 400 ul | 13-15 days | $ 110.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
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ABCC6 predesign siRNA - Additional info | |
| Gene ID | 368 |
| Gene Symbol | ABCC6 |
| Other Names ARA, PXE, MLP1, MRP6, PXE1, URG7, ABC34, MOATE, EST349056, ABCC6 | |
| Format HPLC purified siRNA is supplied as a dried pellet in nmol quantities. | |
| Storage Maintain refrigerated at 2-8°C for up to one week. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
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BACKGROUND
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The encoded protein, a member of the MRP subfamily, is involved in multi-drug resistance. Mutations in this gene cause pseudoxanthoma elasticum. Alternatively spliced transcript variants that encode different proteins have been described for this gene.
REFERENCES
Analysis of MMP2 promoter polymorphisms in patients with pseudoxanthoma elasticum. Zarbock R, et al. Clin Chim Acta, 2010 Oct 9. PMID 20541540. The ERK1/2-hepatocyte nuclear factor 4alpha axis regulates human ABCC6 gene expression in hepatocytes. de Boussac H, et al. J Biol Chem, 2010 Jul 23. PMID 20463007. Novel deletions causing pseudoxanthoma elasticum underscore the genomic instability of the ABCC6 region. Costrop LM, et al. J Hum Genet, 2010 Feb. PMID 20075945. Pseudoxanthoma elasticum: molecular genetics and putative pathomechanisms. Uitto J, et al. J Invest Dermatol, 2010 Mar. PMID 20032990. The R1141X loss-of-function mutation of the ABCC6 gene is a strong genetic risk factor for coronary artery disease. K?bl?s G, et al. Genet Test Mol Biomarkers, 2010 Feb. PMID 19929409.
