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ACACA predesign siRNASynthetic RNA
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| RI10039 | 5 OD 400 ul | 13-15 days | $ 110.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
ACACA predesign siRNA - Additional info | |
| Gene ID | 31 |
| Gene Symbol | ACACA |
| Other Names ACC, ACAC, ACC1, ACCA, ACACA | |
| Format HPLC purified siRNA is supplied as a dried pellet in nmol quantities. | |
| Storage Maintain refrigerated at 2-8°C for up to one week. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
ACACA predesign siRNA - Related products
RI10039: ACACA predesign siRNA
AT1018a: ACACA Antibody (monoclonal) (M01)
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Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.
REFERENCES
Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis. Kim CW, et al. Proc Natl Acad Sci U S A, 2010 May 25. PMID 20457939. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614. Hormonal regulation of acetyl-CoA carboxylase isoenzyme gene transcription. Zhao LF, et al. Endocr J, 2010. PMID 20139635. Acetyl-coenzyme A carboxylase alpha gene variations may be associated with the direct effects of some antipsychotics on triglyceride levels. Diaz FJ, et al. Schizophr Res, 2009 Dec. PMID 19846279. Kidney bean husk extracts exert antitumor effect by inducing apoptosis involving AMP-activated protein kinase signaling pathway. Lee YK, et al. Ann N Y Acad Sci, 2009 Aug. PMID 19723093.
