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ACAN predesign siRNASynthetic RNA
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| RI10045 | 5 OD 400 ul | 13-15 days | $ 110.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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ACAN predesign siRNA - Additional info | |
| Gene ID | 176 |
| Gene Symbol | ACAN |
| Other Names AGC1, SEDK, AGCAN, CSPG1, MSK16, CSPGCP, ACAN | |
| Format HPLC purified siRNA is supplied as a dried pellet in nmol quantities. | |
| Storage Maintain refrigerated at 2-8°C for up to one week. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
ACAN predesign siRNA - Related products
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BACKGROUND
This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene.
REFERENCES
Association between the expression of aggrecan and the distribution of aggrecan gene variable number of tandem repeats with symptomatic lumbar disc herniation in Chinese Han of Northern China. Cong L, et al. Spine (Phila Pa 1976), 2010 Jun 15. PMID 20505571. Lumbar disk degeneration disease and aggrecan gene polymorphism in northern Iran. Mashayekhi F, et al. Biochem Genet, 2010 Aug. PMID 20496110. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614. The interaction between aggrecan gene VNTR polymorphism and cigarette smoking in predicting incident symptomatic intervertebral disc degeneration. Cong L, et al. Connect Tissue Res, 2010 Apr 2. PMID 20367118. A missense mutation in the aggrecan C-type lectin domain disrupts extracellular matrix interactions and causes dominant familial osteochondritis dissecans. Stattin EL, et al. Am J Hum Genet, 2010 Feb 12. PMID 20137779.
