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ACAT1 predesign siRNASynthetic RNA
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| RI10047 | 5 OD 400 ul | 13-15 days | $ 110.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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ACAT1 predesign siRNA - Additional info | |
| Gene ID | 38 |
| Gene Symbol | ACAT1 |
| Other Names T2, MAT, ACAT, THIL, ACAT1 | |
| Format HPLC purified siRNA is supplied as a dried pellet in nmol quantities. | |
| Storage Maintain refrigerated at 2-8°C for up to one week. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
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BACKGROUND
This gene encodes a mitochondrially localized enzyme that catalyzes the reversible formation of acetoacetyl-CoA from two molecules of acetyl-CoA. Defects in this gene are associated with 3-ketothiolase deficiency, an inborn error of isoleucine catabolism characterized by urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, tiglylglycine, and butanone.
REFERENCES
Cholesterol loading in macrophages stimulates formation of ER-derived vesicles with elevated ACAT1 activity. Sakashita N, et al. J Lipid Res, 2010 Jun. PMID 20460577. Analysis of lipid pathway genes indicates association of sequence variation near SREBF1/TOM1L2/ATPAF2 with dementia risk. Reynolds CA, et al. Hum Mol Genet, 2010 May 15. PMID 20167577. A common mutation, R208X, identified in Vietnamese patients with mitochondrial acetoacetyl-CoA thiolase (T2) deficiency. Fukao T, et al. Mol Genet Metab, 2010 May. PMID 20156697. Different clinical presentation in siblings with mitochondrial acetoacetyl-CoA thiolase deficiency and identification of two novel mutations. Th?mmler S, et al. Tohoku J Exp Med, 2010 Jan. PMID 20046049. Leptin modulates ACAT1 expression and cholesterol efflux from human macrophages. Hongo S, et al. Am J Physiol Endocrinol Metab, 2009 Aug. PMID 19625677.
