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ACOX1 predesign siRNASynthetic RNA
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| RI10070 | 5 OD 400 ul | 13-15 days | $ 110.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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ACOX1 predesign siRNA - Additional info | |
| Gene ID | 51 |
| Gene Symbol | ACOX1 |
| Other Names ACOX, SCOX, MGC1198, PALMCOX, ACOX1 | |
| Format HPLC purified siRNA is supplied as a dried pellet in nmol quantities. | |
| Storage Maintain refrigerated at 2-8°C for up to one week. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
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BACKGROUND
The protein encoded by this gene is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Alternatively spliced transcript variants encoding different isoforms have been identified.
REFERENCES
Reversal of mouse Acyl-CoA oxidase 1 (ACOX1) null phenotype by human ACOX1b isoform [corrected]. Vluggens A, et al. Lab Invest, 2010 May. PMID 20195242. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. Lu Y, et al. J Lipid Res, 2008 Dec. PMID 18660489. Peroxisomal acyl-CoA-oxidase deficiency: two new cases. Carrozzo R, et al. Am J Med Genet A, 2008 Jul 1. PMID 18536048. Contribution of peroxisome-specific isoform of Lon protease in sorting PTS1 proteins to peroxisomes. Omi S, et al. J Biochem, 2008 May. PMID 18281296. Clinical, biochemical, and mutational spectrum of peroxisomal acyl-coenzyme A oxidase deficiency. Ferdinandusse S, et al. Hum Mutat, 2007 Sep. PMID 17458872.
