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ACVRL1 predesign siRNASynthetic RNA
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| RI10102 | 5 OD 400 ul | 13-15 days | $ 110.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
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ACVRL1 predesign siRNA - Additional info | |
| Gene ID | 94 |
| Gene Symbol | ACVRL1 |
| Other Names HHT, ALK1, HHT2, ORW2, SKR3, ALK-1, TSR-I, ACVRLK1, ACVRL1 | |
| Format HPLC purified siRNA is supplied as a dried pellet in nmol quantities. | |
| Storage Maintain refrigerated at 2-8°C for up to one week. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
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BACKGROUND
This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.
REFERENCES
Characterization of the human Activin-A receptor type II-like kinase 1 (ACVRL1) promoter and its regulation by Sp1. Garrido-Martin EM, et al. BMC Mol Biol, 2010 Jun 29. PMID 20587022. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. Yokoyama K, et al. Nephron Clin Pract, 2010. PMID 20424473. Update on molecular diagnosis of hereditary hemorrhagic telangiectasia. Richards-Yutz J, et al. Hum Genet, 2010 Jul. PMID 20414677. Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease. Roberts KE, et al. Gastroenterology, 2010 Jul. PMID 20346360. Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesis. Cunha SI, et al. J Exp Med, 2010 Jan 18. PMID 20065063.
