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ADAM17 predesign siRNASynthetic RNA
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| RI10112 | 5 OD 400 ul | 13-15 days | $ 110.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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ADAM17 predesign siRNA - Additional info | |
| Gene ID | 6868 |
| Gene Symbol | ADAM17 |
| Other Names CSVP, TACE, ADAM18, CD156B, MGC71942, ADAM17 | |
| Format HPLC purified siRNA is supplied as a dried pellet in nmol quantities. | |
| Storage Maintain refrigerated at 2-8°C for up to one week. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
ADAM17 predesign siRNA - Related products
AP1492a: ADAM17 Antibody (N-term)
AP1492b: ADAM17 Antibody (C-term)
RI10112: ADAM17 predesign siRNA
DC08282: Human ADAM17 cDNA Clone
LY11937a: ADAM17 Over-expression Lysate
BP1492a: ADAM17 Antibody (N-term) Blocking Peptide
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BACKGROUND
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway.
REFERENCES
ADAM17 regulates epidermal growth factor receptor expression through the activation of Notch1 in non-small cell lung cancer. Baumgart A, et al. Cancer Res, 2010 Jul 1. PMID 20551051. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614. Polymorphisms spanning the TNFR2 and TACE genes do not contribute towards variable anti-TNF treatment response. Potter C, et al. Pharmacogenet Genomics, 2010 May. PMID 20300049. Association of the OCA2 polymorphism His615Arg with melanin content in east Asian populations: further evidence of convergent evolution of skin pigmentation. Edwards M, et al. PLoS Genet, 2010 Mar 5. PMID 20221248. Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation. Xu P, et al. Mol Cell, 2010 Feb 26. PMID 20188673.
