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ADAMTS13 predesign siRNASynthetic RNA
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| RI10117 | 5 OD 400 ul | 13-15 days | $ 110.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
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ADAMTS13 predesign siRNA - Additional info | |
| Gene ID | 11093 |
| Gene Symbol | ADAMTS13 |
| Other Names TTP, VWFCP, C9orf8, vWF-CP, FLJ42993, MGC118899, MGC118900, DKFZp434C2322, ADAMTS13 | |
| Format HPLC purified siRNA is supplied as a dried pellet in nmol quantities. | |
| Storage Maintain refrigerated at 2-8°C for up to one week. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
ADAMTS13 predesign siRNA - Related products
AP7438c: ADAMTS13 Antibody (Center)
RI10117: ADAMTS13 predesign siRNA
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Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene is the von Willebrand Factor (vWF)-cleaving protease, which is responsible for cleaving at the site of Tyr842-Met843 of the vWF molecule. A deficiency of this enzyme is associated with thrombotic thrombocytopenic purpura. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms.
REFERENCES
Human variation in alcohol response is influenced by variation in neuronal signaling genes. Joslyn G, et al. Alcohol Clin Exp Res, 2010 May. PMID 20201926. HLA-DRB1*11: a strong risk factor for acquired severe ADAMTS13 deficiency-related idiopathic thrombotic thrombocytopenic purpura in Caucasians. Coppo P, et al. J Thromb Haemost, 2010 Apr. PMID 20141578. Amino acid residues Arg(659), Arg(660), and Tyr(661) in the spacer domain of ADAMTS13 are critical for cleavage of von Willebrand factor. Jin SY, et al. Blood, 2010 Mar 18. PMID 20075158. Severe malaria is associated with a deficiency of von Willebrand factor cleaving protease, ADAMTS13. L?wenberg EC, et al. Thromb Haemost, 2010 Jan. PMID 20062916. Pathophysiology of thrombotic thrombocytopenic purpura. Tsai HM. Int J Hematol, 2010 Jan. PMID 20058209.
