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AIFM2 predesign siRNASynthetic RNA
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| RI10188 | 5 OD 400 ul | 13-15 days | $ 110.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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AIFM2 predesign siRNA - Additional info | |
| Gene ID | 84883 |
| Gene Symbol | AIFM2 |
| Other Names AMID, PRG3, RP11-367H5.2, AIFM2 | |
| Format HPLC purified siRNA is supplied as a dried pellet in nmol quantities. | |
| Storage Maintain refrigerated at 2-8°C for up to one week. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
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BACKGROUND
The protein encoded by this gene has significant homology to NADH oxidoreductases and the apoptosis-inducing factor PDCD8/AIF. Overexpression of this gene has been shown to induce apoptosis. The expression of this gene is found to be induced by tumor suppressor protein p53 in colon caner cells.
REFERENCES
Functional complementation studies identify candidate genes and common genetic variants associated with ovarian cancer survival. Quaye L, et al. Hum Mol Genet, 2009 May 15. PMID 19270026. DNA binding suppresses human AIF-M2 activity and provides a connection between redox chemistry, reactive oxygen species, and apoptosis. Gong M, et al. J Biol Chem, 2007 Oct 12. PMID 17711848. Bioinformatic and image analyses of the cellular localization of the apoptotic proteins endonuclease G, AIF, and AMID during apoptosis in human cells. Varecha M, et al. Apoptosis, 2007 Jul. PMID 17347867. The human apoptosis-inducing protein AMID is an oxidoreductase with a modified flavin cofactor and DNA binding activity. Marshall KR, et al. J Biol Chem, 2005 Sep 2. PMID 15958387. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
