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CDC6 predesign siRNASynthetic RNA
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| RI10932 | 5 OD 400 ul | 13-15 days | $ 110.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
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CDC6 predesign siRNA - Additional info | |
| Gene ID | 990 |
| Gene Symbol | CDC6 |
| Other Names CDC18L, HsCDC6, HsCDC18, CDC6 | |
| Format HPLC purified siRNA is supplied as a dried pellet in nmol quantities. | |
| Storage Maintain refrigerated at 2-8°C for up to one week. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
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Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins.
REFERENCES
CDC6 interaction with ATR regulates activation of a replication checkpoint in higher eukaryotic cells. Yoshida K, et al. J Cell Sci, 2010 Jan 15. PMID 20048340. [Expression and clinical significance of CDC6 and hMSH2 in cervical carcinoma] Wang WX, et al. Sichuan Da Xue Xue Bao Yi Xue Ban, 2009 Sep. PMID 19950599. A novel androgen receptor-binding element modulates Cdc6 transcription in prostate cancer cells during cell-cycle progression. Jin F, et al. Nucleic Acids Res, 2009 Aug. PMID 19520769. Acetylation by GCN5 regulates CDC6 phosphorylation in the S phase of the cell cycle. Paolinelli R, et al. Nat Struct Mol Biol, 2009 Apr. PMID 19343071. Coordinated activation of the origin licensing factor CDC6 and CDK2 in resting human fibroblasts expressing SV40 small T antigen and cyclin E. Sotillo E, et al. J Biol Chem, 2009 May 22. PMID 19321444.
