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CDK1 predesign siRNASynthetic RNA
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| RI10956 | 5 OD 400 ul | 13-15 days | $ 110.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
CDK1 predesign siRNA - Additional info | |
| Gene ID | 983 |
| Gene Symbol | CDK1 |
| Other Names CDC2, CDC28A, P34CDC2, MGC111195, DKFZp686L20222, CDK1 | |
| Format HPLC purified siRNA is supplied as a dried pellet in nmol quantities. | |
| Storage Maintain refrigerated at 2-8°C for up to one week. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
CDK1 predesign siRNA - Related products
AP1497a: CDC2 Antibody (N-term)
AP1497b: CDC2 Antibody (C-term)
AP3056a: Phospho-CDC2-T161 Antibody
AP3059a: Phospho-CDK1-S39 Antibody
AP3482a: Phospho-CDK1-T14 Antibody
AP7517b: CDC2 (CDK1) Antibody (C-term)
AP7517c: CDK1 Antibody (Center K200)
BP1497a: CDC2 Antibody (N-term) Blocking Peptide
BP1497b: CDC2 Antibody (C-term) Blocking Peptide
BP3056a: Phospho-CDC2-T161 Blocking Peptide
BP3059a: Phospho-CDK1-S39 Antibody Blocking Peptide
BP3482a: Phospho-CDK1-T14 Antibody Blocking Peptide
BP7517b: CDK1 Antibody (C-term) Blocking Peptide
BP7517c: CDK1 Antibody (Center K200) Blocking Peptide
BP7517d: CDK1 Antibody (T14) Blocking Peptide
BP7517e: CDK1 Antibdoy (Y15) Blocking Peptide
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BACKGROUND
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
REFERENCES
Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest. Harley ME, et al. EMBO J, 2010 Jul 21. PMID 20526282. Centrosome-related genes, genetic variation, and risk of breast cancer. Olson JE, et al. Breast Cancer Res Treat, 2010 May 28. PMID 20508983. Cdk1 activity is required for mitotic activation of aurora A during G2/M transition of human cells. Van Horn RD, et al. J Biol Chem, 2010 Jul 9. PMID 20444701. Phosphorylation of mixed lineage leukemia 5 by CDC2 affects its cellular distribution and is required for mitotic entry. Liu J, et al. J Biol Chem, 2010 Jul 2. PMID 20439461. Progressive activation of CyclinB1-Cdk1 coordinates entry to mitosis. Gavet O, et al. Dev Cell, 2010 Apr 20. PMID 20412769.
