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CTLA4 predesign siRNASynthetic RNA
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| RI11303 | 5 OD 400 ul | 13-15 days | $ 110.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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CTLA4 predesign siRNA - Additional info | |
| Gene ID | 1493 |
| Gene Symbol | CTLA4 |
| Other Names CD, GSE, GRD4, ICOS, CD152, CTLA-4, IDDM12, CELIAC3, CTLA4 | |
| Format HPLC purified siRNA is supplied as a dried pellet in nmol quantities. | |
| Storage Maintain refrigerated at 2-8°C for up to one week. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
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BACKGROUND
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
REFERENCES
Carriage of a tumor necrosis factor polymorphism amplifies the cytotoxic T-lymphocyte antigen 4 attributed risk of primary biliary cirrhosis: evidence for a gene-gene interaction. Juran BD, et al. Hepatology, 2010 Jul. PMID 20578265. CTLA-4 gene polymorphism +49 A/G contributes to genetic susceptibility to two infection-related cancers-hepatocellular carcinoma and cervical cancer. Hu L, et al. Hum Immunol, 2010 Sep. PMID 20538028. The CTLA4 variants may interact with the IL23R- and NOD2-conferred risk in development of Crohn's disease. Hradsky O, et al. BMC Med Genet, 2010 Jun 10. PMID 20537165. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. Schuurhof A, et al. Pediatr Pulmonol, 2010 Jun. PMID 20503287. Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers. Plant D, et al. Ann Rheum Dis, 2010 Aug. PMID 20498205.
