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DAB1 predesign siRNASynthetic RNA

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United States
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Ordering Information
Catalog # Size Availability Price  
RI11403 5 OD 400 ul 13-15 days $ 110.00 Add to cart
  • Specification
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DAB1 predesign siRNA - Additional info

Gene ID1600
Gene SymbolDAB1
Other Names
DAB1
Format
HPLC purified siRNA is supplied as a dried pellet in nmol quantities.
Storage
Maintain refrigerated at 2-8°C for up to one week. For long term storage store at -20°C.
Precautions
This product is for research use only. Not for use in diagnostic or therapeutic procedures.

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Provided below are standard protocols that you may find useful for product applications.

BACKGROUND

The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.

REFERENCES

Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614. Common genetic variation and the control of HIV-1 in humans. Fellay J, et al. PLoS Genet, 2009 Dec. PMID 20041166. Involvement of Dab1 in APP processing and beta-amyloid deposition in sporadic Creutzfeldt-Jakob patients. Gav?n R, et al. Neurobiol Dis, 2010 Feb. PMID 19853035. Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells. Yang XV, et al. Proc Natl Acad Sci U S A, 2009 Jan 6. PMID 19116273. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. Uhl GR, et al. Arch Gen Psychiatry, 2008 Jun. PMID 18519826.